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pentobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may improve the metabolism of ifosfamide to its active alkylating metabolites.pentobarbital will reduce the extent or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Wa